PaTRIC is the UK arm of an international audit evaluating real-world transfusion practices in hospitalised patients with cirrhosis, focusing on platelet and coagulation factor replacement.

To register interest, please email suzanne.maynard@ouh.nhs.uk

Key information

Contacts

UK Project lead: Suzanne Maynard University of Oxford
Consultant lead: Simon Stanworth University of Oxford / OUH / NHSBT

Documents/Links

Timeline

  • Data collection: March – June 2026 (select your data collection window at site set up)

  • Abstract submission: Summer/Autumn 2026

  • Manuscript submission: Winter 2026

Background

Transfusion of procoagulant blood components (platelets, fresh frozen plasma (FFP), cryoprecipitate and fibrinogen) is common in cirrhosis, but practice varies widely between centres. Recent ISTH guidance recommends against prophylactic transfusion driven solely by abnormal laboratory values, reflecting “rebalanced haemostasis” in cirrhosis. Unnecessary transfusions should be avoided as they can cause harm and waste valuable resources.  PaTRIC will describe current UK practice, compare it with guidance, and provide centre-level feedback to support quality improvement and standardisation.

Aims

Primary objective:
Measure the prevalence, patterns and indications for platelet, FFP, cryoprecipitate and fibrinogen concentrate use in hospitalised patients with cirrhosis, and compare practice with ISTH standards.

Secondary objectives:
- Evaluate clinical outcomes associated with inpatient use of procoagulant blood components in patients with cirrhosis (e.g., mortality, VTE and bleeding).
- Develop simple, effective feedback formats (including data visualisation) to improve engagement and nudge practice towards guideline alignment.

Eligibility criteria

  • Inclusion: All adult admissions with cirrhosis (by imaging, biopsy or clinician documentation) during your sites 2-3 weeks data collection period.

  • Exclusion: patients <18 years.

What does participation involve?

Follow the site set up steps:

  • Step 1: Register PaTRIC locally

  • Step 2: Find your team

  • Step 3: Complete site registration

Following successful site set up, and receipt of RedCAP logins, get ready for your 2-3 week data collection window (see site set up for dates) and get collecting!